Living systems are complex, nonlinear, dynamical, self-organizing systems possessing innate energy fields imbued with bio-information vital to life processes. Moreover, they continually exchange matter and energy-with-information within and across multiple levels of organization to heal, maintain themselves, and advance or evolve. This course will provide a scientific overview of holistic biotonic principles that are central to the organism, with a focus on the bioenergy field or biofield. Such holistic field concepts have played central roles in the traditional worldviews and healing systems of all indigenous cultures on earth. Both Eastern and Western biofield concepts will be covered in this course. The biofield concepts may be essential to building an appropriate scientific foundation for energy medicine. The world view clashes with mainstream science and medicine—as well as opportunities for reconciliation—will be explored. The course will conclude with a review of recent progress in biofield theory and experiment, an exploration of the relationship between biofields and consciousness, and an assessment of various directions for future research.